Ch6 Gas Transport by the Blood-Ch 6(1)

Ch6 Gas Transport by the Blood-Ch 6(1) - Gas Transport by...

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Gas Transport by the Blood-Ch 6 Questions 1. What is the difference between the Bohr and Haldane effects? 2. What is the Henderson-Hasselbalch equation used for? 3. What is standard bicarbonate? The oxygen dissociation curve does shift(right) if blood acidity significantly changes. This is called the Bohr effect. Acidic blood(lower pH) holds less oxygen as shown in the plot below. A change of blood pH from the normal 7.4 to 7.2 is a very large change. In a normal person, this is usually only occurs if blood PaCO2 is about 60 mm Hg. So the Bohr effect can be considered as connected with pH or PCO2 . The Bohr effect promotes delivery of oxygen to the tissues (high saturation in lungs-low saturation in tissue). Temperature also shifts the curve, but body temperature is maintained constant at 37 degrees so this is not a factor within the body. The Haldane effect is named for the vertical shift in the carbon dioxide dissociation curve. De-oxygenated blood can carry more CO2 from the tissues(venous blood).
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3 - ), 5% dissolved, and 5% bound by Hemoglobin(Caramino). Arterial blood pH, PCO2, and HCO 3 - are linked by the Henderson- Hasselbalch equation: pH = 6.1 + log10( ) Using this equation, given any two variables the third could be calculated. In the usual application, pH and PCO2 are measured and HCO3- is calculated. Terumo Medical continuous pH, PCO2, PO2 monitor for open heart surgery.
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Ch6 Gas Transport by the Blood-Ch 6(1) - Gas Transport by...

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