10-20-2011 bone repair

10-20-2011 bone repair - Bone Ti B Tissue Engineering E i i...

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Bone Tissue Engineering For BME 410 10-20-2011 Bo Han, Ph.D epartment of Surgery and BME Department of Surgery and BME 1333 San Pablo St. MMR-210 os Angeles CA 90089 Los Angeles, CA 90089 323-442-2242 bohan@usc.edu
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rthopedic Surgery Orthopedic Surgery
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Treatments in Orthopedics Repair eplacement Regeneration Replacement g
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oly Grails of Orthopedics Holy Grails of Orthopedics one Regeneration ± Bone Regeneration ± Cartilage Regeneration ± Intervertebral Disc ± Ligament/Tendons
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issue Gardening Tissue Gardening ± Seeds ± Water & Fertilizer ± Soil and Trellis
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Tissue Engineering Signaling Factors Cells Scaffolds
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one Anatomy Bone Anatomy
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one Grafts Bone Grafts ± Autogenous bone = “ old Standard” Gold Standard ± Need for Substitute ± Large defect ± Small defect ontaminated ± Contaminated autograft
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one Grafts Bone Grafts caffold ± Osteoconductive Scaffold e.g., Porous ceramic ignaling Factors, ± Osteoinductive Signaling Factors, e.g., TGF- β , BMP2, OP-1 ± Osteogenetic esponding Cells Responding Cells, e.g., steoblasts Stem Cells Osteoblasts, Stem Cells
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utograft Autograft PROS CONS ± Osteogenic steoinductive ± Donor Site orbidity ± Osteoinductive steoconductive Morbidity ± Limited ± Osteoconductive ± Non-immunogenic Quantity ± Non-pathogenic ± Unpredictable uality Quality
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one Graft Substitutes Bone Graft Substitutes ± Xenografts ± Allografts ± Ceramics ± Stem Cell ± Growth Factors
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oals for Bone Grafts Goals for Bone Grafts ± Stimulate Bone regeneration ± Space fill ± Biomechanical ± Resorb
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ioceramics Bioceramics ± Bioinert luminum Oxide ± Aluminum Oxide ± Zirconium Oxide ± Bioactive (Calcium Salts) ± Calcium Phosphates: HA, TCP, DCP alcium Carbonates ± Calcium Carbonates ± Calcium Sulfates ± Bioactive Glasses (Silicates)
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ydroxyapatite Hydroxyapatite a H) O ater rganic Matrix Ca 10 (OH) 2 (PO 4 ) 6 Cells 1% Water 8% Organic Matrix 21% ± Mineral Content of Bone, Dentin and Enamel ± Biocompatible steophilic, Bioactive Hydroxyapatite 70% ± Osteophilic, Bioactive ± Osteoconductive ± Soluble and Resorbable
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Blocks Granules
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situ Cement In situ Cement Calcium Phosphate Calcium Sulphate
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steoconductivity Osteoconductivity Canine Radial Diaphysis
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ypes of Allograft Types of Allograft ---“ issue Bank” Tissue Bank ± Fresh Frozen ± Freeze Dried, “lyophilized” ± Demineralized Bone Matrix (DBM)
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orms of Allograft Forms of Allograft
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Demineralized Bone Matrix DBM can induce ectopic bone formation in animal odels models Different forms of DBM and DBM with carriers are used in clinical application over 20 years. pp y MPs, TGF- IGF, PDGF, etc. ctive growth factors BMPs, TGF β , IGF, PDGF, etc. Collagen I--control release evice Active growth factors Scaffold device Urist, M. R. (1965). “Bone: formation by autoinduction.” Science 150 (698): 893-9 Huggins, C. B. and M. R. Urist (1970). “Science 167 (919): 896-8.
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steoinductivity f DBM : Areas of implants; implant can be in the form of owder sheet putty gel 2 ¾ Osteoinductivity Osteoinductivity of DBM of DBM 1 2 powder, sheet, putty, gel Explanted after 28 days or designated time 3 5 4 6
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This note was uploaded on 02/15/2012 for the course BME 410 taught by Professor Han during the Fall '08 term at USC.

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10-20-2011 bone repair - Bone Ti B Tissue Engineering E i i...

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