Hsiai_BME-tissue engineering-11-17-11

Hsiai_BME-tissue engineering-11-17-11 - Interfacing...

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Unformatted text preview: Interfacing Bioengineering with Injured and Interfacing Bioengineering with Injured and Regenerating Myocardium Regenerating Myocardium zung zung siai siai MD PhD MD PhD Tzung Tzung Hsiai Hsiai , MD, PhD , MD, PhD Biomedical Engineering and Cardiovascular Medicine Biomedical Engineering and Cardiovascular Medicine University of Southern California University of Southern California C ardiovascular ardiovascular E ngineering ngineering R esearch esearch C ore ore Shear stress Pressure (a) (b) dif user contraction 0.5 10 Pressure sensor temperature sensor 55 flow dif user contraction 0.5 10 Pressure sensor temperature sensor 55 flow dif user contraction 0.5 10 Pressure sensor temperature sensor 55 flow 400x monocytes BAEC 400x monocytes BAEC 80 m An array of shear stress sensors 80 m 80 m An array of shear stress sensors 10 150 20 Stres (dyne/cm2) 2 4 S t re s (d yn e /c m2) Velocity profile Bulk resistance Oxidative stress 75% 50% 25% Integrated flexible polymer- t d (1) Computational Fluid Dynamics (2) vascular oxidative stress and mechanically unstable plaque (3) Mechanosignal transduction Endothelial cel (units: mm, not to scale) Endothelial cel Endothelial cel (units: mm, not to scale) 50 1 2 3 4 Shear Time (sec)-4-2 1 2 3 4 S he a r Time (sec) pulsatile shear stress oscil atory shear stress (a) (b) Angiogram ECG coated MEMS and n 4PP Blood flow 4mm NIH R01 HL083015-06 NIH R01 HD069305-01 NIH R01 HL111437-01 NIH R21 HL091302-02 NIH R21 CA149543-01 AHA PDF Rabdominal aorta 1.2 mm Rabdominal aorta 1.1 mm Normal diet High fat diet aorta 10 20 30 40 50 60 Inlet velocity waveform regenerated using Fourier analysis with 12 harmonics velocity, U c ( cm/s) Velocity waveform Mean velocity = 14.0891 cm/s 30 40 50 60 ress, dynes/cm 2 ) Computed original WSS Computed WSS in the presence of coaxial wire Measured ISS from the wire-based sensor (a) (b) (c) (d) 2 cm catheter MEMS sensor aorta R R P T Voltage (V) valves Caltech, UCLA, UCSD, LA Childrens (4) Rabbit model of atherosclerosis Four-point nano-probe Coaxial wire catheter Weight: Mnormal=16g Weight: Mhyper=23g Raortic arch 1.8 mm Raortic arch 1.5 mm 0.05 0.1 0.15 0.2 0.25 0.3-20-10 Time within one cycle, t (sec) Center-line v 0.05 0.1 0.15 0.2 0.25 0.3 10 20 Time within one cardiac cycle, t (sec) Shear str (a) Time (ms x10 4 ) (b) Time (ms x 10 4 ) R R R R R P T Voltage (V) ST ST ST Ventricle 80 m Flexible Sensor ) (6) F lexible polymer sensors (7) Micro-ECG to monitor Zebrafish heart regeneration ) AEC nd 50 m Plaque MEMS shear stress sensor th t (a) 10 m LDLR-null (5) Deployment of intravascular sensors (8) HAEC and tube formation (9) Ultrafine particles catheter (b) catheter C 5 15 30 1hr 2hr Phospho- JNK total-JNK n Interdisciplinary Approach n Interdisciplinary Approach An Interdisciplinary Approach An Interdisciplinary Approach Linking shear stress with tissue repair and Wnt Linking shear stress with tissue repair and Wnt target Angiopoeitin target Angiopoeitin-2...
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This note was uploaded on 02/15/2012 for the course BME 410 taught by Professor Han during the Fall '08 term at USC.

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Hsiai_BME-tissue engineering-11-17-11 - Interfacing...

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