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Perin First hour 1

Perin first hour 1

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Unformatted text preview: Childrens Hospital Los Angeles Department of Urology Saban Research Ins=tute University of Southern California Amnio&c Fluid, Stem Cells and their applica&ons Laura Perin, PhD 1. Amnio=c fluid and its role during development 2. Characteriza=on of the cellular popula=on within amnio=c fluid 3. Amnio=c fluid stem cells (AFSC) 4. Embryonic Kidney and Tissue Engineering 5. AFSC: Kidney and Lung Regenera=on 1. Amnio&c Fluid Amnio&c fluid is the liquid that surrounds the developing fetus during pregnancy 4 1. 2. Protec&ng the fetus from outside injury by cushioning sudden blows or movements Maintaining a rela&vely constant temperature around the fetus, thus protec&ng the fetus from heat loss Acts as a barrier to infec&on Func=ons : 3. 4. Allowing lungs and guts to develop properly 5. Allowing the fetus freedom to move and enabling the skeleton to develop properly Amnio=c Fluid Exchange All these exchanges are finally regulated in order to maintain a constant volume of AF In early fetal period, before kera&niza&on of the skin, the AF volume and fetal size are related in linear fashion. There is a free permeabiliza&on between amnion, placenta and umbilical cord. At 8 weeks of gesta&on the fetal kidney develops and start to produce urine and swallowing begins AKer kera&niza&on (19-20 weeks) the rela&onship between fetal size and AF volume is not linear anymore; at this point the AF is predominately accomplished by excre&on of fetal urine and by secre&on of oral, nasal, tracheal and pulmonary fluids. There is also a fluid and solutes exchange from the amnio&c cavity to the fetal circula&on across the amnio&c membranes. 1. High volume of amnio&c fluid i.e. more than 2000 ml is called Polyhydramnios. It results when the fetus does not swallow the usual amount of amnio&c fluid e.g. in esophageal atresia Pathology: 2. Low volume of amnio&c fluid i.e. less than 400 ml is called Oligohydramnios. It can deve...
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