9_1_11_InterCellAndCell-ECMInteractions

9_1_11_InterCellAndCell-ECMInteractions - Outline of the...

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Outline of the Lecture Inter-cellular and Cell-ECM communications Intracellular Signals Cell-adhesion molecules Integrin
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Inter-cellular Communication Uses Intracellular Signaling, Cell Adhesion Molecules, and Integrin-ECM Interactions
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In this course, we will try to understand the rules of inter-cellular interactions in tissue formation.
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A final concept of importance to tissue engineering is the scaffold, here shown for cardiovascular tissue-engineered conduits.
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Today, we will focus on the mechanisms of interactions between cells, and between cells and the extracellular matrix.
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Eukaryotic cells have multiple organelles, e.g., the nucleus and the endoplasmic reticulum.
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Transcription factors regulate expression of genes by activating their promoter regions.
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Inter-cellular communi- cation uses four main types of intracellular signal- transduction pathways. Genzyme Biosurgery
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Inter-cellular signaling can target the cell cycle (also key for cell culture): mitosis (M), DNA replication (S), and two inter phases (G1, G2).
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We identify two types of cell division: cleavage (a), which in cultures may lead to exponential growth (c), and asymmetric (b), as with stem cells (d). Genzyme Biosurgery
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Micro- tubules are part of the cytoskeleto n (a), which can control cell shape (b), help in transport (c), and separate chromo- somes in mitosis (d). Genzyme Biosurgery
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Microfilaments of the cytoskeleton, change cell shape (a), divide cells (b), and cause motility (c).
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molecules may be the Ca 2+ - dependent cadherins (a), Ca 2+ - independent cell adhesion molecules (CAMs — b), and integrins (c). Genzyme Biosurgery
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9_1_11_InterCellAndCell-ECMInteractions - Outline of the...

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