PS 3 answers, probs 8+9+10

PS 3 answers, probs 8+9+10 - for mapping studies. If a...

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Problem 8. a) This is a most likely a dominant phenotype . b) There is evidence of linkage. Notice that the i B often occurs in individuals affected by the disease. c) If we call the wild-type allele of the nail-patella gene “n” and the dominant mutant allele “N”, both of the grandfather’s chromosomes had the i and n alleles. The grandmother had one chromosome with the i and n alleles, and one with the i B and N alleles. d) In generation 2, individuals 5 and 8 appear to be recombinants. In generaton 3, individual 3 is a recombinant. Problem 9. If an individual is homozygous for an allele at a microsatellite, all of their gametes will have the same allele. The microsatellite therefore can not be used as a marker to distinguish the parental and recombinant gametes, and so will not be useful
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Unformatted text preview: for mapping studies. If a locus has few alleles and low heterozygosity, many individuals in a population will share the same genotypes. Problem 10 A) Given the sequence fragment from the standard allele below, write the corresponding sequence for the Super Sweaty allele Standard allele: 5-ATGGCACCCGATCGATTCGCTACTGA-3 Super Sweaty allele: 5-ATGGCACCCG C TCGATTCGCTACTGA-3 B) Autosomal recessive C) Fill in the bands on the gel below for as many family members as possible. MW 1 2 3 4 5 6 7 8 9 10 11 12 13 14 NOTE: lane 6 should have two bands as well, just like person 4 and 14 D) Individuals 3, 5, 7, 8, 10, 13 can be either heterozygous or homozygous. 500bp 700bp 1000bp...
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This note was uploaded on 02/15/2012 for the course PMB 13 taught by Professor Freeling during the Spring '09 term at University of California, Berkeley.

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