PS 3 answers, prob 1 - If this child grows up, gets...

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LS4 Problem Set 3, 2010 Positional Cloning, RFLPs, microsatellites Answers Problem 1. Microsatellite allele A is 300bp (largest, closest to top of gel), allele B is 200bp, allele C is 150bp, and allele D is 50bp (smallest, closest to bottom of gel). Genotype the family (which alleles does each individual have) Mom: BC (carrier, allele C has mutation) Dad: AD (carrier, allele A has mutation) First Child: AC (since first child affected with recessive phenotype, these must be the mutant alleles) Fetus: AB (carrier, allele A from father has mutation) What is the probability that the unborn child will have trouble with bladder control? 0% - The fetus is a carrier of the mutation.
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Unformatted text preview: If this child grows up, gets married, and has a child, what is the probability that their child will have trouble with bladder control? 0.5 * .12 * 0.5 = .03 [0.5 chance that carrier (fetus is known to be a carrier) will pass on mutated allele] * [0.12 chance that random individual in population is a carrier] * [0.5 chance that carrier will pass on mutated allele] If they have one child that has trouble with bladder control, what is the probability that they will have another child with bladder control problems? 0.5*0.5 = 0.25 If they had a child homozygous recessive for BC mutation, then they must both be carriers....
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