Problem 4. A gene encoding a blood clotting factor has two alleles, A and a. Another gene on a different chromosome also encoding a blood clotting factor has two alleles, B and b. A random sample of individuals was taken and tested for their blood clotting factors for these two genes. The following distribution was obtained: AA BB 202 Aa BB 101 aa BB 101 AA Bb 372 Aa Bb 186 aa Bb 186 AA bb 166 Aa bb 83 aa bb 83 This represents 1480 people. A) Is the population at H-W equilibrium for the A gene? How about the B gene? (Show your work) Assume that both genes are at H-W equilibrium (although they may not be). B) After one generation of random mating, what fraction of the next generation will be AA (independent of the B gene)? C) After one generation of random mating, what fraction of the next generation will be BB (independent of the A gene)? D) What is the chance that the first child of a Aa Bb female and a AA Bb will be a Aa bb male? (Hint: Do you need to consider allele frequencies to solve this problem? Think
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This note was uploaded on 02/15/2012 for the course PMB 13 taught by Professor Freeling during the Spring '09 term at Berkeley.