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MCB 410 Spring Study questions on cell adhesion

MCB 410 Spring Study questions on cell adhesion - MCB 410...

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MCB 410 Spring Study questions on cell adhesion, ECM and transplantation. Describe the major functions of tight junctions, gap junctions, adherens junctions, desmosomes,hemi-desmosomes, and focal adhesions. Give an example of where each of these occurs and in what cell types. How are each of these junctions connected to the cytoskeleton. When viewed face-on, the tight junctions that seal the edges of epithelial cells appear as anetwork of seals (Fig.19-4). This is in contrast to the multiple rings of seals (the rings) whichseal the pistons in a gas engine. Why is a network of seals advantageous to ensure the sealsstay tight? (optional for future automotive engineers and car mechanics,: why aren’t piston rings designed this way?)
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During embryonic development cells move and change their attachments to both the ECM and to neighboring cells. They do this by regulating the binding properties of their cell surface molecules. For each of the following cell surface molecules, state whether its regulation would effect interactions with the ECM or with neighboring cells and explain your answer. Whichinteractions are homophilic and which are heterophilic.
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