Levey - Predictive Health Course 4_11

Levey - Predictive Health Course 4_11 - Predictive Health:...

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Unformatted text preview: Predictive Health: Predicting and Preventing Alzheimers Disease Allan I. Levey, M.D., Ph.D. Allan I. Levey, M.D., Ph.D. Professor and Chair Professor and Chair Department of Neurology Department of Neurology Emory University Emory University The Dementia Epidemic- A Global Crisis Alzheimer Alzheimer s Disease s Disease Frontotemporal Frontotemporal Dementia Dementia Parkinson Parkinson s Dementia s Dementia Lewy Body Dementia Lewy Body Dementia Vascular Dementia Vascular Dementia MANY others MANY others The Dementia Epidemic $315 billion annual costs worldwide More expensive than heart disease, cancer, and stroke combined The Alzheimers Disease Epidemic . . . ~ 5 million today . . . nearly 50% over age 85 have AD . . . 70 million baby boomers . . . ~$150 B annual costs today . . . US Population > 85 years old (in millions) Recent Trends in Alzheimers Disease Mortality in the United States, 1999-2004 Steenland et al. 2009 Alzheimers Disease Mortality Rates: U.S. 1999-2004 22.6-34.4 (3 rd Tercile) 18.5-22.5 (2 nd Tercile ) 8.1-18.3 (1 st Tercile) D.C. *Deaths per 100,000, standardized by age, race, sex to US 2000 p opulation. Relative Mortality Rate 16 per 100,000 21 per 100,000 Data from the National Center for Health Statistics files using AD as underlying cause of death (ICD-10) Mild Cognitive Impairment Changing the Course of Alzheimers Disease Cognition Cognition Preclinical Stages Mild Mild Dementia Dementia Moderate Moderate Dementia Dementia Severe Severe Dementia Dementia Age Age 50 55 60 65 70 75 80 85 90 1. Early Detection 2. Disease Modification Neurodegeneration and Brain Atrophy Control Alzheimers Disease Pathology of Alzheimer's Disease Brain Atrophy Plaques Plaques Tangles Tangles Alois Alzheimer Research into the Cause of Alzheimers Disease Alzheimer s Disease: A Complex Trait with Genetic and Environmental Factors Alzheimer Alzheimer s s Disease Disease Alzheimer Alzheimer s s Disease Disease Genes Environment Risk or Protective factors...
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This note was uploaded on 02/15/2012 for the course ANTHRO 231 taught by Professor Dr.lampl during the Spring '11 term at Emory.

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Levey - Predictive Health Course 4_11 - Predictive Health:...

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