PredictiveHealthLecture-Miller[2]

PredictiveHealthLecture-Miller[2] - Predictive Health and...

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Predictive Health and Parkinson’s disease Gary W. Miller, Ph.D., Department of Environmental and Occupational Health Rollins School of Public Health Center for Neurodegenerative Disease Gary.miller@emory.edu
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Parkinson’s disease 2nd most common neurodegenerative disorder Afflicts over 1,000,000 U.S. Citizens Cardinal signs of bradykinesia, tremor, rigidity, and postural instability Risk factors- age, pesticide exposure, family history Protective factors- smoking, caffeine consumption
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DiMonte et al., Neurotoxioclogy 2002 Epidemiological studies linking pesticides to Parkinson’s disease
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PESTICIDES INSECTICIDES FUMIGANTS HERBICIDES RODENTICIDES FUNGICIDES Pyrethroids - Type I - Phenothrin - Type II - Cypermethrin, Deltamethrin Anticholinesterases - Organophosphates - Parathion, Chlorpyrifos - Carbamates - Aldicarb, Methomyl Avermectins - Ivermectin Other - Nitromethylene - Chlor-onicotinyl - Phenylpyrazole Organochlorines - Cylclodienes - Dieldrin, Heptachlor - Dichlorodiphenylethanes - DDT, methoxychlor - Cyclohexanes Botanicals - Nicotine - Rotenoids - Rotenone, Deguelin Phophine Ethylene dibromide/ dibromochloropropane Bipyridyls - Paraquat Diquat Chloroacetanilides - Alachlor Chlorophenoxy Compounds - 2,4-dichlorophenoxyacetate Phosphomethyl amino acids - Glyphosate Hexachlorobenze Pentachlorophenol Phthalamides - Captan, Folpet Dithiocarbamates - Maneb, Ziram Zinc Phosphide Fluoroacetate Derivatives α-naphthyl thiourea Anticoagulants - Diphacinone, Bromdadialone
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Aldrin/dieldrin 1900 1910 1920 1930 1940 1950 1960 1970 1980 1990 2000 Permethrin 2010 Maneb Paraquat DDE/DDT Rotenone Chlorpyrifos use phase-out persistence . Introduction, use, and persistence of major pesticides/PCBs in U.S. Trends in Pharmacological Sciences., 2008 PCBs
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Trends in Pharmacological Sciences., 2008
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MPTP, Paraquat, Rotenone N+-CH3 MPP + “Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis ( MPTP
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PredictiveHealthLecture-Miller[2] - Predictive Health and...

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