Raison Mar 1 2011

Raison Mar 1 2011 - Mental Health and the Mind-Body...

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Unformatted text preview: Mental Health and the Mind-Body Connection What does compassion have to do with it? Charles L. Raison, M.D. Associate Professor Department of Psychiatry & Behavioral Sciences Emory University School of Medicine Atlanta, GA What are the primary impediments to Lifelong Health and Wellbeing? The future and the past have different appearances the disproportion will always be great between expectation and enjoyment, between new possession and satiety the truth of many maxims of age gives too little pleasure to be allowed till it is felt the miseries of life would be increased beyond all human power of endurance, if we were to enter the world with the same opinions as we carry from it. Samuel Johnson, The Rambler #196-Psychosocial Stress-Sickness What are the primary impediments to Lifelong Health and Wellbeing? Whats so bad about psychosocial stress Part I ? How can stress cause sickness? What is sickness? CYTOKINES INTERLEUKIN-6 What is sickness? CYTOKINES INTERLEUKIN-6 Stress, inflammation and depression How do we know stress activates inflammation? Pace et al., Am J Psychiatry , 2006. Plasma IL-6, pg/ ml 1 2 3 4 5 6-15 15 30 Major Depression (n = 14) Control (n = 13) TSST * *Between group comparison, p < 0.05 +Within group comparison vs. 0 min time pt, p < 0.05 Plasma IL-6, pg/ ml 1 2 3 4 5 6-15 15 30 45 60 75 90 Medically Health Men WITH Major Depression (n = 14) Medically Health Men WITHOUT Major Depression (n = 13) STRESS Time (min) *Between group comparison, p < 0.05 +Within group comparison vs. 0 min time pt, p < 0.05 + + + + * + + * Psychosocial Stress Activates Inflammation: Effect of Depression Relationship between Proinflammatory Cytokines and Hippocampal Volume Marsland et al. Biol Psychiatry 2008;64:484-90 Higher cytokine levels were associated with diminished hippocampal gray matter volume in 76 non-depressed adults-4.00-3.00-2.00-1.00 0.00 1.00 2.00 3.00 4.00-1-0.8-0.6-0.4-0.2 Adj. Left Hippocampal Volume (z-units) IL-6 (inverse pg/mL) r2 = 0.19 P<0.01 We cannot learn real patience and tolerance from a guru or a friend. They can be practiced only when we come in contact with someone who creates unpleasant experiences. According to Shantideva, enemies are really good for us as we can learn a lot from them and build our inner strength. H.H. The Dalai Lama Why Study Compassion Meditation in Particular? What is Compassion Meditation? Atisha and the Tea Server.....
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Raison Mar 1 2011 - Mental Health and the Mind-Body...

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