Soltow PredictiveHealth_class

Soltow PredictiveHealth_class - Emory Clinical Biomarkers...

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Healthy Aging and Predictive Health Quinlyn A. Soltow, PhD Department of Medicine/Division of Pulmonary, Allergy and Critical Care Medicine Emory University, Atlanta April 8, 2010 Emory Clinical Biomarkers Laboratory
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Outline Aging vs. Healthy Aging Metabolomics Assessing unhealthy aging Frailty among others Future of personalized medicine
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What is aging?
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What is aging? Dictionary : Length of time during which a being or thing has existed. Wikipedia : Accumulation of changes in an organism or object over time.
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What is healthy aging?
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Predictive Health: Global signatures integrate effects of diet, lifestyle, environment and genetics, and these can be used to predict health and disease outcomes Global Signatures Health, Disease Diet, behavior Environmental Exposures Genetics, Epigenetics
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-Omics Era (Information-rich technologies) e End-point of enzymatic processes Most predictive of phenotype
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Metabolic Profiles Health and Disease Outcome Diet, Behavior Environmental Exposures Metabolic profiles integrate effects of diet, lifestyle, environment and genetics Genetics, Epigenetics Predictive Health & Metabolomics
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One drop of blood 10-min run time Finnigan LTQ FT Liquid Chromatography-Fourier Transform Mass Spectrometry (LC-FTMS) Jennifer Johnson, Fred Strobel
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R e l a t i v n s y M / c h r g T m Detail Metabolic Signatures Detailed metabolic landscape of plasma is revealed by LC-FTMS: relative abundance of about 2500 metabolic features
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What is unhealthy aging? Cancer Diabetes Heart disease Atherosclerosis/hypercholesterolemia Osteoporosis Sarcopenia Malnutrition Anemia Alzheimer’s disease and Depression Frailty
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Defining Frailty Complex syndrome affecting multiple
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This note was uploaded on 02/15/2012 for the course ANTHRO 231 taught by Professor Dr.lampl during the Spring '11 term at Emory.

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Soltow PredictiveHealth_class - Emory Clinical Biomarkers...

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