Unformatted text preview: Exposed hydrophobic peptides, that are usually buried in the core of proteins, are recognized during both heat shock and the unfolded protein response. 5. Give one reason why scrapies was thought not to be due to viral infection. (2 points) Because it was not sensitive to UV irradiation or ionizing radiation, which damage nucleic acids. 6. How does GroEL-GroES affect the energetic protein-folding funnel? (4 points) By smoothing the folding funnel in two ways. It prevents aggregation of folding intermediates, making dips in the funnel less deep. It also provides an optimal folding environment, decreasing energetic barriers, making hills smaller. What is the function of ATP hydrolysis in the GroEL-GroES cycle? (2 points) To recycle the chamber for folding of other proteins. Although binding to ATP allows the chamber to form, hydrolysis does not directly affect the rate of folding of the client protein....
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- Winter '10
- DNA, unfolded protein response, Double Stranded DNA, energetic protein-folding funnel