Lect 7 - Tissues IV

Lect 7 - Tissues IV - Lecture 7: Integrating Cells into...

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Lecture 7: Integrating Cells into Tissues IV - Question and Answer session will be Monday 8- 10 PM. Room TBD. - No assignment due and no discussion sections next week.
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Claudins make the tight-junction strands that form the inter-cellular seals Claudin 1
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Experimental evidence that claudins form the “pores” that regulates ion transport in the tight junctions 15 PNSYW R VSTVHGNVITTNTIF E NLWFSCAT D SLGVYNCW E FPSMLALSQYIQAC R Claudin 15 Loop 1 E46 K D 55 R E64 K Adapted from Dr. J. M. Anderson, UNC
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Tight junctions are also signaling and cytoskeletal organization centers
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Major junctions in epithelia and other cells Figure 6-5 Focal adhesion Stress fibers
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Major junctions: focal adhesions Figure 6-26
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Major junctions: Integrin-containing focal adhesions and hemidesmosomes
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Integrin-based adhesions are critical cytoskeletal organization and signaling centers Ben-Ze’ev, A. (1997) Current Opinion in Cell Biology 9 , 99-108
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Junctional organization depends on cell environment Figure 6-27
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Figure 6-28
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This note was uploaded on 02/16/2012 for the course BIOL_SCI 315 taught by Professor Beitel during the Spring '10 term at Northwestern.

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Lect 7 - Tissues IV - Lecture 7: Integrating Cells into...

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