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Tuberculosis - Tuberculosis PeterLuckow MichaelHeller...

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    Tuberculosis Peter Luckow Michael Heller
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History 4,000 years ago  – apparent tuberculosis cases  throughout the world 460 BC  – Hippocrates notes consumption in  patients 1500’s  – Growth of urban population led to  epidemics 1800-1850  –  ¼  Europeans died of TB 1850  – Urban renewal of Paris 1850  – Major reduction in tuberculosis related  deaths
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History (cont.) 1865  – Jean-Antoine Villemin inoculated rabbits with TB from  cadavers 1882  – Robert Koch proved that TB was caused by a bacterium Late 1800’s  – Edward Trudeau’s experiment gave a means of  treatment, leading to sanitariums Late 1800’s  – Increased European immigration to the United  States  Early 1900’s  – Better screening of incoming immigrants 1906  – Calmette and Guerin produce an attenuated M. bovis  strain (later used as a vaccine) 1946  – Schatz and Waksman discover streptomycin Mid 1980’s  – TB cases dramatically increased 
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Origin of Tuberculosis Domestication of cattle led to the passage of TB- like disease from cattle to human Hippocrates – tuberculosis was inherited Aristotle – observed TB’s contagious nature Mid 1600’s – Controversy between two thoughts Migration of Indo-European cattle herders Increased migration from rural to urban areas
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Estimated number of TB cases in 2000
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Basic facts TB kills 2 million per  year 2000-2020 1 billion will be newly  infected 200 million people will  get sick 35 million will die from TB
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Disease and transmission TB is contagious and  spreads through the air Each person with TB will  infect an average of 10 to 15  people per year Someone is newly infected  every second 1/3 of the world’s population  is infected
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Mycobacterium tuberculosis MTB  is the cause of TB Aerobic bacterium Divides every 16 to 20 hours
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