11.3.09 Lecture - Mitosis

11.3.09 Lecture - Mitosis - 11/3/09 Mitosis: Segregating...

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11/3/09 Mitosis: Segregating chromosomes in somatic cells. The short list. -Condense all of the chromosomes -Build a bipolar spindle out of microtubules -Connect the spindle microtubules to the chromosomes -Check that all chromosomes are connected -Separate sister chromatids -Mechanically move the chromosomes to opposite poles -Break it all down and signal for cell division Condense the DNA prior to mitosis so that individual chromosomes can move without becoming entangles. Condensation is an ATP dependent even using condensing proteins. They look a lot like motors. 1 st step toward spindle contrsuction is the semi-conservative duplication of the centrosome. When both centrosomes are competent for polymerization, microtubule motors (kinesins) are required to force the centrosomes apart, beginning the process of spindle contstruction. Centrosome duplication and movement occur prior to nuclear envelope breakdown at prometaphase. Most cancer tissues have cell with over-duplicated centrioles.
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11.3.09 Lecture - Mitosis - 11/3/09 Mitosis: Segregating...

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