{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

11.3.09 Lecture - Mitosis

11.3.09 Lecture - Mitosis - Mitosis Segregating chromosomes...

Info icon This preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
11/3/09 Mitosis: Segregating chromosomes in somatic cells. The short list. -Condense all of the chromosomes -Build a bipolar spindle out of microtubules -Connect the spindle microtubules to the chromosomes -Check that all chromosomes are connected -Separate sister chromatids -Mechanically move the chromosomes to opposite poles -Break it all down and signal for cell division Condense the DNA prior to mitosis so that individual chromosomes can move without becoming entangles. Condensation is an ATP dependent even using condensing proteins. They look a lot like motors. 1 st step toward spindle contrsuction is the semi-conservative duplication of the centrosome. When both centrosomes are competent for polymerization, microtubule motors (kinesins) are required to force the centrosomes apart, beginning the process of spindle contstruction. Centrosome duplication and movement occur prior to nuclear envelope breakdown at prometaphase. Most cancer tissues have cell with over-duplicated centrioles.
Image of page 1

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Image of page 2
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern