32 - Chapter 32: Nonspecific (Innate) Host Resistance I....

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Chapter 32: Nonspecific (Innate) Host Resistance I. Host Resistance Overview A. Immunity= ability of a host to resist infection or disease A.1. Nonspecific immune response = (aka nonspecific resistance & innate or natural immunity) first line of defense against foreign material; defends against foreign invaders equally and lacks immunological memory A.2. Specific immune response= (aka acquired, adaptive or specific immunity) resists a particular foreign agent; effectiveness increases on repeated exposure to foreign agents/have “memory” A.3. Hematopoiesis= blood cell development II. Physical Barriers in Nonspecific (innate) resistance A. Physical and mechanical barriers A.1. Skin : keratinocytes produce keratins (scleroproteins=insoluble) and shed; pH 5 to 6 due to skin oil, secretions from sweat glands, organic acids produced by commensal staphylococci; high concentration of NaCl, and periodic drying A.2. Mucous membranes: stratified squamous epithelium and mucus secretions form a protective covering that resists penetration and traps many
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32 - Chapter 32: Nonspecific (Innate) Host Resistance I....

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