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LectureNotes36 - [email protected] Cam Maj new pmpprh’e 95716[MA{15 a...

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Unformatted text preview: 2W @6 Cam Maj new. pmpprh’e? 95716 [MA {15 a Camp/ex wH’A Maia; “er unwed/{cm and NH; hjands i5 odaAfidy-M/ feMApdrd, w fyaare P/ahar? PM do L":— kmow 7’1? Mém'ca/ {GA/Maj ’16, N4.1+ f f QQWLJVM ( @934? 4/; W P“— ———- -— [email protected]/€_ Gigi-Wer Cf: E G’PHMLJJM W167: { x HAM are ______—— W744 €— 45 H 695% Mm,- E C§§ 5345mm MM W W N Wflshajmgg [2:24 22 MWFMC‘ @ _ 4 H1314 {pm —Luw §pm Exerme 5‘ 3 5295(wa bulk/L3 (H1026321L [g Farah/La? M‘Q [Pecwufiw Wampum. 807% AM WM Fe Civ— /(’/0 HLO E 61x51“ daL E dxflla. d1. dxq 42% d”)? ( 4K7 4,36% d9; @6 How WWW? Wired e" me Win 411% 3 60% {UM [ca @431") [comméjzj M [£0 (Nugflqf‘ [away—4 60 +4C€' 60 [AT] MAW/[IA her/a444,; Wit/1AA; Md! mmww m. a 140% 7’ ——. _ E 4X7 a!er [ HM NW‘M/e‘ 4x14”, {EL [Camméfw‘ _" C0 4- éHLO 7; / —_——- E { 42W? 42’- HWI—‘H “W7?! 6"— ——.—_.|--——— fil‘X-j 4%} P“) 2‘ [CDOVl/Iflb] 2+-————$ CO _{_ T E d>‘"7L 0912‘ _ I HM MW'NJ e ,——-—"—"-—"’ aim dye 0972 O C "F’N N \ / ® H—c Fe C——H Ci \ 9N” \i / HO——C~CH2PCH2 CH3 \ \C / CH3 \ CH==CH2 H End. 0F Mr W Ms W Figure 23.7 fracture of hemoglobin. protein molecuies con» groups are packed into the hemoglobin structure. Adapted from R. E. Dickerson and I. Geis, The Structure and Action of Pro- teins, W. A. Benjamin, Ina, Menio Park, Calif, 1969‘ Original illustra- tion copyright 1969 by R. E. Dick— erson and I‘ Geis‘ Quaternary 5 Four globular mining heme / CHZCHECONHQ [ Vitamin BIZ Figure 7—24 A zinc ion is coordinated to two histi— dine side chains and a glutamate side chain at the active site of carboxypcp— tidase A. A water molecule coordi- nated to the zinc is not shown here. [After D. M. Blow and T. A. Steitz. X—ray diffraction studies of enzymes, Ann. Rev. Bier/um. 39:78. Copyright © 1970 by Annual Reviews, Inc. All rights reserved] TIM». Figure 7—23 * JL Three-dimensional structure of carboxypeptidase A. Only S I (fit/‘4 the a~carbon atoms and the zinc ion (shaded circle near the center) are shown. [From W. N. Lipscomb. Prov. Robert A. l Weld! Found. Conf. Chem. Res. 15(1971j:134.] ...
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