01. ForensicDNA Rev 2

01 ForensicDNA Rev - Forensic Science DNA Prof J T Spencer 1 DNA Deoxyribonucleic Acid What are nucleic Acids Structure of DNA DNA vs RNA Blue

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1 Forensic Science: DNA Prof. J. T. Spencer
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2 DNA Deoxyribonucleic Acid What are nucleic Acids Structure of DNA DNA vs. RNA “Blue print” of life How it “transcribes” life Where is it located Forensic Applications
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3 DNA Timeline of DNA 1868 Miescher “discovers” DNA 1953 Watson and Crick report double helix structure 1977 First human gene cloned. 1985 Jeffreys reports VNTR DNA sequences 1985 First report of PCR method 1986 Jeffreys uses DNA to solve first murder case (Picthfork case) 1987 First conviction on DNA evidence (Andrews case) 1991 STRs first reported 1998 FBI starts CODIS database 2005 2.5 million DNA “finger-prints” in FBI database
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Forensic DNA: Two Tales 4 Colin Pitchfork Case (1986) WTC Case (2001)
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5 How DNA Works: Nucleic Acids Nucleic Acids - chemical carriers of genetic information (DNA and RNA). Consist of; A phosphoric Acid Molecule (H 3 PO 4 ) A five carbon Sugar (ribose) A nitrogen containing base CH 2 C H OH H OH OH H C C C H O HO CH 2 C H OH H OH H H C C C H O HO DEOXYRIBOSE DEOXYRIBOSE RIBOSE RIBOSE
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6 Nucleic Acids CH 2 C H H OH H H C C C H O O N N N N NH 2 P O O O -1 -1 Phosphate Phosphate Sugar Sugar Base Base Three “Building Blocks” linked through  condensation reactions to form polymers. Nucleotide - unit of the three building blocks  (phosphate, sugar, and base) Nucleotide Nucleotide
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7 Nucleic Acids: Bases N N N N NH 2 N N N N O NH 2 N N NH 2 O N N H 3 C O O N N O O Adenine Adenine Guanine Guanine Cytosine Cytosine Thymine Thymine (DNA Only) (DNA Only) Uracil Uracil (RNA Only) (RNA Only)
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8 Nucleic Acids Nucleic Acid Polymer (i.e., DNA) Phosphate Phosphate Sugar Sugar Base Base Phosphate Phosphate Sugar Sugar Phosphate Phosphate Sugar Sugar Phosphate Phosphate Base Base Base Base Polymer Polymer
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9 Nucleic Acids Nucleic Acid Polymer (i.e., DNA) O
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10 Nucleic Acids Double Helix - Hydrogen Bonds
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11 Nucleic Acids Double Helix - Hydrogen Bonds physics.bu.edu/~neto/ Topic6.htm N N N N N N N N N O N N N N O N N C H 3 O O A T G C H H H H H H H O H H 2 C H O P O O O O P O O O O H H 2 C H O P O O O O H C H 2 O O P O O O P O O O O H C H 2 O P O O O H y d r o g e n B o n d s H y d r o g e n B o n d s H H
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12 Base Pairs Hydrogen Bonding
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13 DNA Structure Major Groove Minor Groove
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14 DNA Structure
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15 DNA in the Cell chromosome cell nucleus Double stranded DNA molecule Individual nucleotides
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DNA Structure (1) Information in the order of nucleotides in DNA can be transcribed and translated to direct the preparation of proteins in the cell. (2) Every three nucleotides in DNA codes for one amino acid in the formation of a protein. (3) Parts of DNA coding for proteins are called genes. (4) DNA contains very large
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This note was uploaded on 02/20/2012 for the course CHE 113 taught by Professor Spencer during the Spring '08 term at Syracuse.

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01 ForensicDNA Rev - Forensic Science DNA Prof J T Spencer 1 DNA Deoxyribonucleic Acid What are nucleic Acids Structure of DNA DNA vs RNA Blue

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