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2-1f_regulation_of_aa_synthesis

2-1f_regulation_of_aa_synthesis - tyrosine inhibits the...

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Feedback inhibition schemes for the control of amino acid biosynthesis The activity of amino acid biosynthetic enzymes is often controlled by feedback inhibition. The first irreversible reaction in a pathway is usually the target of regulation. The final product of the pathway is usually the inhibitor. Inhibition schemes include sequential feedback control , enzyme multiplicity , and concerted feedback control.
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Classical example of feedback inhibition: regulation of threonine deaminase A B C D E Z threonine α -ketobutyrate isoleucine
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QuickTimeª and a decompressor are needed to see this picture. Feedback inhibition by tryptophan anthranilate synthase anthranilate phosphoribosyl transferase
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Regulation of branched biosynthetic pathways Sequential Feedback Control D E Y A B C F G Z
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Example of sequential feedback inhibition: aromatic amino acid biosynthesis in B. subtilis Chorismate inhibits the DAHP synthase
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Unformatted text preview: tyrosine inhibits the dehydrogenase and phenylalanine inhibits the dehydratase Inhibition of the prephenate branches in B. subtilis Enzyme multiplicity D E Y A B C F G Z Two different enzymes catalyze the first common step. Example of enzyme multiplicity: aromatic amino acid synthesis in E. coli three different enzymes catalyze this step one is inhibited by tyrosine one is inhibited by phenylalanine one is inhibited by tryptophan QuickTimeª and a decompressor are needed to see this picture. Example of enzyme multiplicity: aromatic amino acid synthesis in E. coli (continued) two different mutases catalyze this step. one is inhibited by phenylalanine one is inhibited by tyrosine Concerted feedback control D E Y A B C F G Z inhibition by (Y + Z) Inhibition is more than additive. Concerted feedback inhibition is not observed in amino acid biosynthesis!!!...
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2-1f_regulation_of_aa_synthesis - tyrosine inhibits the...

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