04-Antitermination

04-Antitermination - The regulation of transcription...

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The regulation of transcription termination in prokaryotes Antiterminate Terminate Regulator factors bind RNA, act processively by modifying polymerase Ribosome regulates termination at a specific site Regulatory factors bind RNA, act at specific site tRNA regulates termination at specific site by forming RNA complex. Not depicted-regulatory factor binds DNA at promoter and modifies polymerase, leading to processive action.
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Hairpin or stem-loop structure For mechanisms b, c, d, e-Regulation of formation of a terminator hairpin
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1 2 3 4 1 2 3 4 1 2 3 4 Alternate stem-loop structures result Terminate Regulation by control of alternative structures RNA No Termination
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Transcriptional attenuation Transcription terminator at a specific site within an operon is regulated by particular metabolic signal Numerous examples employing fundamentally different mechanisms for controlling transcription termination Amino acid biosynthetic operons of enteric bacteria Basis- two mutually exclusive secondary structures The region between the first structural gene and the promoter-leader Efficiency of translating leader peptide determines which secondary structure forms Transcription and translation coupled
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Cartoon of alternative secondary structures for attenuation at amino acid biosynthetic operons of E. coli
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The leader peptide contains multiple residues of the amino acid whose biosynthesis is regulated
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Structure of the leader region of the trp operon of E. coli terminator antiterminator
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04-Antitermination - The regulation of transcription...

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