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452_nukes - 6 Sources of reducing power for rNDP reductase...

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Biochemistry 452 Study Guide for Nucleotide Metabolism bold=profs favorites I. Knowing what you are talking about. Structures: PRPP NAD and NADP CoA FAD, FMN carried forward: isoalloxazine ring, S-adenosylmethionine II. Pathways and regulation. 1. Biosynthesis of IMP starting from PRPP. 2. Pathways from IMP to AMP and GMP. 3. Allosteric regulation of purine de novo synthesis. (and use of ATP to make GMP and GTP to make AMP). 4. De novo synthesis of pyrimidines. 5. Regulation of pyrimidine de novo synthesis in E. coli and animals.
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Unformatted text preview: 6. Sources of reducing power for rNDP reductase. 7. Relationship between thymidylate synthase and enzymes of tetrahydrofolate metabolism. III. Enzyme reaction mechanisms. 1. FGAM synthetase 2. OMP decarboxylase 3. Class I rNDP reductase. 4. Thymidylate synthase. IV. Clinical Biochemistry 1. Gout. 2. Lesch-Nyhan Syndrome. 3. SCID. 4. Inhibitors of dihydrofolate reductase and why used in chemotherapy....
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