E2-histones

E2-histones - Cartoon showing the position of H1 H1...

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Cartoon showing the position of H1 H1 occupies an asymmetric position, contacting two gyres
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Under certain conditions, H1 is released and the nucleosomes can be extended like beads on a string.
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Artistic depictions of chromosome packaging
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Structure of the nucleosome core particle Notes: molecular “handshake” 4-helix bundle mediates H2B-H4 interaction
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Cartoon of histone fold and histone H1 The histone fold is also found in some transcription factors. The helices have highly basic surfaces that interact with DNA.
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Assembly of the nucleosome H3 + H4 ------> H3/H4 heterodimer-----> H4/H3-H3/H4 tetramer H2A + H2B---> H2A/H2B heterodimer------------> c H2A n / n H2B c -- c H4 n / n H3 c -H3/H4--H2B/H2A binds 120 bp DNA regulation of this interaction is thought to play an important role in controlling core structure.
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Cartoon of nucleosome core structure
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Tails of the histone proteins. The tails of the histone proteins are the sites of regulatory covalent modifications Types of covalent modification acetylation methylation phosphorylation ubiquitination
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Histone tails interact with other nucleosomes and other scaffolding proteins to affect chromatin structure
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C-terminal tail of H2A interacts with DNA no linker DNA linker DNA present interactions deduced from crosslinking experiments
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This note was uploaded on 02/17/2012 for the course CHEM 212 taught by Professor Staff during the Fall '10 term at Rutgers.

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E2-histones - Cartoon showing the position of H1 H1...

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