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eukaryotic_studyguide - Study Guide for Eukaryotic...

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Study Guide for Eukaryotic Transcription. [Note: there were several different powerpoints, and the slide numberrs refer to the relevant powerpoint] 1. How many genes does the human have, and how does this compare to the number of genes found in bacteria and yeasts? 2. How does the size of the human genome compare to the size of the bacterial and yeast genomes? 3. What fraction of human DNA comprises genes that encode products? 4. What is the “selfish DNA” hypothesis. 5. What is the packaging ratio of Eukaryotic DNA? What is the difference between euchromatin and heterochromatin? 6. Using a simple diagram, describe the arrangement of subunits within the nucleosome octomer, and indicate (on the diagram or in text) which interactions are four-helix bundles and which interactions are molecular handshake. What are the role of the N- terminal tails of the histones? 7. What is the “histone-code” hypothesis that is used to explain certain instances of bistability of gene expression?
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