immuno-08c

immuno-08c - Complex interactions between different cell...

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Complex interactions between different cell types controls antibody production and cytotoxic T-cell activity
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T cells recognise antigens in combination with MHC gene products MHC restriction
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The T-cell receptor is related to immunoglogulins Diversity generated as with immunoglobulins. Human: α chain has VJC 50V, 70J = 3500 different β chain has VDJC 57V, 13J, 2D=1482 different combinatorial gives 5,187,000 different variability in recombination junctions and mutation thought to increase to much larger number, perhaps as high as 10 12
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The T-cell receptor, immunoglobulins, and Class I and Class II MHC proteins are part of an immunoglobulin superfamily
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Human MHC locus is highly polymorphic Class I MHC proteins: ~44 kDa, always associated with β 2 -microglobulin (12 kDa). α 3 domain and β 2 -microglobulin assume the immunoglobulin fold α 1 and α 2 domains form an 8 stranded β sheet and 2 α helices that form an antigen-presentation “cup”. The antigen site holds an 8-10 aa polypeptide.
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This note was uploaded on 02/17/2012 for the course CHEM 212 taught by Professor Staff during the Fall '10 term at Rutgers.

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immuno-08c - Complex interactions between different cell...

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