int-metabolism

int-metabolism - Integration of Metabolism Metabolic...

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Integration of Metabolism }
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QuickTimeª and a GIF decompressor are needed to see this picture. Metabolic interactions of the major organs
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QuickTimeª and a GIF decompressor are needed to see this picture. Fuel Store Preferred Exported glycogen amino acids glucose triacyl- glucose fatty acids glycerols fatty acids ketone bodies triacyl- fatty acids fatty acids glycerols glycerol glycogen fatty acids alanine glucose lactate none fatty acids none none glucose none ketone bodies Metabolic Profiles of the Major Organs
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The Cori Cycle is one of the mechanisms that permits the muscles to run up an “oxygen debt”
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Metabolic Adaptation Fed State 6 -12 hrs 1-3 days 3 days Starvation Blood glucose ~ 6 mM. Liver and muscle make glycogen. Liver uses amino acids and fatty acids. Triaclyglycerols stored in adapose cells. Blood glucose ~ 4.5 mM. Liver uses muscle amino acids to make and export glucose. Triacylglycerols split and the glycerol is used by the liver to make glucose. Fatty acids used by liver and muscle. Carbohydrate reserves depleted. Muscle rapidly degraded to amino acids. Triacylglycerols used. Liver makes ketone bodies (Citric acid cycle slows). The switch to ketone body production is coordinated with a decrease in the rate of protein degredation in muscle.
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Major metabolic pathways and control sites: glycolysis Fructose-6-phosphate ATP Phosphofructokinase Activated by F-2,6-BP Activated by AMP and ADP ADP Inhibited by ATP Inhibited by citrate Fructose-1,6-bisphosphate Glycolysis is controlled by the need for ATP (ATP/AMP ratio) and by the need for building blocks (citrate).
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Major metabolic pathways and control sites Citric Acid cycle: citrate synthase, isocitrate dehydrogenase, and 2-ketoglutarate dehydrogenase are inhibited by ATP Pentose phosphate pathway: Glucose-6-P dehydrogenase is controlled by NADP + Gluconeogenesis: Key regulatory site is fructose-1,6-bisphosphatase Fructose-1,6-bisphosphate H 2 O Fructose-1,6-bisphosphatase Activated by citrate Inhibited by AMP Inhibited by fructose-2,6-BP Pi Fructose-6-phosphate
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int-metabolism - Integration of Metabolism Metabolic...

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