Lecture12_topo_v2_2012 (1)

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Unformatted text preview: 1 2 QuickTime and a TIFF (Uncompressed) decompressor are needed to see this picture. Nothing in biology makes sense except in the light of evolution T. Dobzhansky Salvador Dali Imagination is more important than knowledge, for knowledge is limited while imagination embraces the entire world. Albert Einstein Biochemistry 441 Lecture 13 Ted Young February 8, 2012 Biochemistry 441 Lecture 13 Ted Young February 8, 2012 Topics for today: DNA tertiary structure and DNA topoisomerases urls for supercoiling and topoisomerase urls for supercoiling and topoisomerase youtube link for supercoilng demonstration: http://www.youtube.com/watch?v=k4fbPUGKurI http://www-dna2006.cea.fr/lectures/Roca1.pdf (lectures 7 and 8):http://vohweb.chem.ucla.edu/voh/classes%5CWinter08%5C153BID42% This lecture has some good exercises you can perform with simple material to better understand DNA supercoiling. http://www.mikeblaber.org/oldwine/bch5425/bch5425.htm http://rpi.edu/dept/bcbp/molbiochem/BiochSci/sbello/new_page_1.htm This lecture has some good exercises you can perform with simple material to better understand DNA supercoiling. Exercise: Study B-DNA structure at: http://stingray.bio.cmu.edu/~web/bc/LecS01/Lec34/1BNA.html 5 6 Comparison of open and supercoiled DNA molecules by electron microscopy Comparison of open and supercoiled DNA molecules by electron microscopy R G R G R G (open circle) > R G(supercoiled) This difference accounts for the greater mobility...
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Lecture12_topo_v2_2012 (1) - 1 2 QuickTime and a TIFF...

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