Lecture16_Recomb_2012

Lecture16_Recomb_2012 - 1 2 3 “Nothing in life is to be...

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Unformatted text preview: 1 2 3 “Nothing in life is to be feared. It is only to be understood.” Marie Curie Biochemistry 441 Lecture 10 Ted Young February 17,2012 Biochemistry 441 Lecture 10 Ted Young February 17,2012 Topic for today: DNA recombination We will only discuss homologous recombination (pp 978-985 in your text) Videos on DNA repair, recombination Videos on DNA repair, recombination Two short videos on DNA recombination: http://www.youtube.com/watch?v=gQFKdA3VgEg This is a very short clip-showing the Holliday junction cleaved both ways-to give non- recombinants with a conversion in the middle, and a cut after swiveling the junction 180o that gives reciprocal recombination. http://www.youtube.com/watch?v=xS6bJMcOrAk Short clip of NHEJ-non-homologous end-joining-a mechanism to recombine/repair broken chromosomes that doesn’t require extensive homology. 5 6 Homologous genetic recombination: Why recombine? Homologous genetic recombination: Why recombine? 1 . Evolutionary argument: increase fitness of populations-experimental support from micro- organisms. 2. Molecular rationale: proper segregation at meiosis. Experimental support: mutants that can’t recombine can’t complete meiosis 3. DNA repair-associated recombination. 4. DNA replication requires recombination in some organisms. 5. Recombination can regenerate telomeres in the absence of telomerase 7 Recombination occurs during meiosis in germ- line cells, rarely or not at all in...
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This note was uploaded on 02/17/2012 for the course CHEM 212 taught by Professor Staff during the Fall '10 term at Rutgers.

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Lecture16_Recomb_2012 - 1 2 3 “Nothing in life is to be...

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