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Unformatted text preview: the signal transduction. [Eg. slides 28 and 29, or slide 43] 7. Briefly describe the role of ligand binding in activation of receptor tyrosine kinases, and the roles of autophosphorylation on the activation loops and outside the kinase domain. [slides 37 and 39, among others] 8. Describe the roles of each of the following domains: SH2 SH3 PTB pleckstrin homology domain chromodomain bromodomain 9. Using a simple cartoon, describe the JAK-STAT pathway for relaying cytokine signals. (Slide 43). 10. Using a cartoon diagram, describe how a protein growth factor, acting through a receptor tyrosing kinase, can act through Ras and a MAP kinase cascade to control gene expression. (Slide 44). 11. Using a cartoon diagram, show how an external signal, acting through a G-protein coupled receptor, can bring about activation of PLC and by so doing bring about activation of PKC and other cellular kinases. (Slide 53)....
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- Fall '10
- pH, Pertussis, two-component signal transduction, Signal Transduction Section