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signal_transduction_studyguide - the signal transduction[Eg...

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Study Guide for Signal Transduction Section, 2008 Biochemistry 452 1. What are the catalytic activities of bacterial two-component signal transduction systems such as the NRI/NRII system ? [Slides 5 and 6] 2. Using a simple diagram, describe the phosphorylation events that occur during signalling of the two-component systems performing osmotic sensing, oxygen sensing, and sporulation control. [Slide 10] 3. Provide an example of how a two-component system works to control a MAP kinase cascade in yeast. [Slide 13] 4. Describe the proteins involved in bacterial chemotaxis, and give a brief description of the role of each protein. [Slide 17] 5. Using cartoon diagrams, describe the role of cholera toxin and pertussis toxin in altering the level of the second messenger, cAMP. Draw the structure of the chemical modification brought about by these toxins [slides 24, 25]. 6. Provide a complete example of how a signal outside the cell can cause a change in the level of transcription of a gene, naming all the important components that participate in
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Unformatted text preview: the signal transduction. [Eg. slides 28 and 29, or slide 43] 7. Briefly describe the role of ligand binding in activation of receptor tyrosine kinases, and the roles of autophosphorylation on the activation loops and outside the kinase domain. [slides 37 and 39, among others] 8. Describe the roles of each of the following domains: SH2 SH3 PTB pleckstrin homology domain chromodomain bromodomain 9. Using a simple cartoon, describe the JAK-STAT pathway for relaying cytokine signals. (Slide 43). 10. Using a cartoon diagram, describe how a protein growth factor, acting through a receptor tyrosing kinase, can act through Ras and a MAP kinase cascade to control gene expression. (Slide 44). 11. Using a cartoon diagram, show how an external signal, acting through a G-protein coupled receptor, can bring about activation of PLC and by so doing bring about activation of PKC and other cellular kinases. (Slide 53)....
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