Chronic_Renal_Failure

Chronic_Renal_Failure - Chronic Renal Failure There are...

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
Chronic Renal Failure There are three major mechanisms that are involved in the pathogenesis of chronic renal failure: 1) decreased excretion of water and electrolytes; 2) decreased excretion of organic solutes (uremic toxins); and 3) decreased renal hormone synthesis. The kidney has a considerable physiologic reserve. Even with damage to ¾ of the total number of nephrons, the remaining ¼ are able to compensate and maintain balance. Effective compensation occurs until the GFR drops below 20% of normal. However, beyond this point the decreased Na + and water filtration causes edema and hyponatremia; the decreased K + secretion causes hyperkalemia; the decreased NH 4 + secretion causes a metabolic acidosis, and the decreased PO 4 - filtration causes hyperphosphatemia. The buffering of the acidosis by bone and skeletal muscle results in osteopenia and a loss of lean body mass and muscle weakness. The first defect in the cascade of pathophysiological events is phosphate retention when the GFR declines to 50-60
Background image of page 1
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 02/17/2012 for the course MPAS PA 602 taught by Professor Dr.laird during the Fall '10 term at Chatham University.

Ask a homework question - tutors are online