Hyperlipidemia_treatment

Hyperlipidemia_treatment - HDL-C, elevated TG VLDL hepatic...

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Table 350-6 Summary of the Major Drugs Used for the Treatment of Hyperlipidemia Drug Major Indications Starting Dose Maximal Dose Mechanism Common Side Effects HMG -CoA reductase inhibitors (statins) Elevated LDL-C Cholestero l synthesis, hepatic LDL receptors, VLDL production Myalgias, arthralgias, elevated transaminases, dyspepsia Lovastatin 20 mg daily 80 mg daily Pravastatin 40 mg qhs 80 mg qhs Simvastatin 20 mg qhs 80 mg qhs Fluvastatin 20 mg qhs 80 mg qhs Atorvastatin 10 mg qhs 80 mg qhs Rosuvastatin 10 mg qhs 40 mg qhs Cholesterol absorption inhibitors Intestinal cholesterol absorption Elevated transaminases Ezetimibe Elevated LDL-C 10 mg daily 10 mg daily Bile acid sequestrants Elevated LDL-C Bile acid excretion and LDL receptors Bloating, constipation, elevated triglycerides Cholestyramine 4 g daily 32 g daily Colestipol 5 g daily 40 g daily Colesevelam 3750 mg daily 4375 mg daily Nicotinic acid Elevated LDL-C, low
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Unformatted text preview: HDL-C, elevated TG VLDL hepatic synthesis Cutaneous flushing, GI upset, elevated glucose , uric acid, and liver Immediate-100 mg 1 g tid Drug Major Indications Starting Dose Maximal Dose Mechanism Common Side Effects release tid function tests Sustained-release 250 mg bid 1.5 g bid Extended-release 500 mg qhs 2 g qhs Fibric acid derivatives Elevated TG , elevated remnants LPL, VLDL synthesis Dyspepsia, myalgia, gallstones, elevated transaminases Gemfibrozil 600 mg bid 600 mg bid Fenofibrate 145 mg qd 145 mg qd Omega 3 fatty acids Elevated TG 3 g daily 6 g daily TG catabolism Dyspepsia, diarrhea, fishy odor to breath Note: LDL, low-density lipoprotein; VLDL, very low density lipoprotein; HDL, high-density lipoprotein; LDL-C, LDL-cholesterol; HDL-C, HDI-C, cholesterol; TG, triglyceride; LPL, lipoprotein lipase; GI, gastrointestinal....
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Hyperlipidemia_treatment - HDL-C, elevated TG VLDL hepatic...

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