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Unformatted text preview: HDL-C, elevated TG VLDL hepatic synthesis Cutaneous flushing, GI upset, elevated glucose , uric acid, and liver Immediate-100 mg 1 g tid Drug Major Indications Starting Dose Maximal Dose Mechanism Common Side Effects release tid function tests Sustained-release 250 mg bid 1.5 g bid Extended-release 500 mg qhs 2 g qhs Fibric acid derivatives Elevated TG , elevated remnants LPL, VLDL synthesis Dyspepsia, myalgia, gallstones, elevated transaminases Gemfibrozil 600 mg bid 600 mg bid Fenofibrate 145 mg qd 145 mg qd Omega 3 fatty acids Elevated TG 3 g daily 6 g daily TG catabolism Dyspepsia, diarrhea, fishy odor to breath Note: LDL, low-density lipoprotein; VLDL, very low density lipoprotein; HDL, high-density lipoprotein; LDL-C, LDL-cholesterol; HDL-C, HDI-C, cholesterol; TG, triglyceride; LPL, lipoprotein lipase; GI, gastrointestinal....
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- Fall '10