Hyperlipoproteinemias

Hyperlipoproteinemias - -- to + ++ to +++ LDL-cholesterol...

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Table 350-3 Frederickson Classification of Hyperlipoproteinemias Note: LPL, lipoprotein lipase; apo, apolipoprotein; FCS, familial chylomicronemia syndrome; FH, familial hypercholesterolemia; FDB, familial defective apoB; ARH, autosomal recessive hypercholesterolemia; ADH , autosomal dominant hypercholesterolemia; FCHL, familial combined hyperlipidemia; FDBL, familial dysbetalipoproteinemia; FHTG, familial hypertriglyceridemia Phenotype I IIa IIb III IV V Lipoprotein, elevated Chylomicro ns LDL LDL and VLDL Chylomicron and VLDL remnants VLDL Chylomicro ns and VLDL Triglycerides ++++ -- ++ ++ to +++ ++ ++++ Cholesterol + to ++ +++ ++ to ++ + ++ to +++
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Unformatted text preview: -- to + ++ to +++ LDL-cholesterol HDL-cholesterol +++ + ++ ++ ++ +++ Plasma appearance Lactescent Clear Clear Turbid Turbid Lactescent Xanthomas Eruptive Tendon, tuberous None Palmar, tuberoerupti ve None Eruptive Pancreatitis +++ +++ Coronary atheroscleros is +++ +++ +++ +/ +/ Peripheral atheroscleros is + + ++ +/ +/ Molecular defects LPL and apoC-II LDL receptor, ApoB-100, PCSK9, ARH, ABCG5 and ABCG8 Unknow n ApoE ApoA-V and Unknow n ApoA-V and Unknown Genetic nomenclature FCS FH, FDB, ADH , ARH, sitosterolem ia FCHL FDBL FHTG FHTG...
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