Hyponatremia_pathophysiology - Question: Why is there...

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Hyper volemia ECF ↑↑ Total Body Na + H 2 O gain > Na + gain Effective arterial vol. CHF Cirrhosis Renal Failure Euvolemia ECF  Total Body Na +   Small H 2 O gain  Effective arterial vol. normalized SIADH Hypothyroidism Hypocortisolism Beer Potomania Psychogenic polydipsia Hypovolemia ECF Total Body Na + ↓↓ Na + loss > H 2 O loss Effective arterial vol. normalized Thiazide diuretic Addison’s disease GI losses Renal Na + wasting Hypoosmolal Hyponatremia Question: Why is there euvolemia when there is an increase in the extracellular fluid (ECF)? Answer: There is either a persistent release of AVP (SIADH, hypothryoidism, hypocortisolism) or an increase in the intake of fluids (Beer potomania, psychogenic polydipsia) that causes an increase in the ECF. Note that all of these disorders affect fluid reabsorption or intake and not Na + . This is an increase in water reabsorption without a significant increase in Na + reabsorption. This increase in the ECF does not cause a hypervolemia
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This note was uploaded on 02/17/2012 for the course MPAS PA 602 taught by Professor Dr.laird during the Fall '10 term at Chatham University.

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Hyponatremia_pathophysiology - Question: Why is there...

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