Renal_Physiology_11

Renal_Physiology_11 - Renal Function n Regulate osmotic...

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Unformatted text preview: Renal Function n Regulate osmotic pressure n Regulate ion concentration n Regulate extracellular fluid volume n Regulate acid base balance n Remove metabolic waste products n Remove drugs & toxins n Synthesize hormones 1 2 3 4 5 6 7 Glomerular capsule Lamina densa 8 9 Membranoproliferative glomerulonephritis 2nd ary MPGN Diseases SLE Hep B & C Endocarditis HIV Leukemia Lymphoma 10 Glomerular Disease Mechanism Injury Pathology Disease Clinical Idiopathic 1)Minimal Change Disease 2)Focal Glomerulosclerosis 2) multiple Nephrotic Immune Complex Subepithelial Membranous nephropathy SLE, Hep B & C, NSAIDS Nephrotic Acute Proliferative GN Post-infectious (late phase) Nephrotic Subendothelial & Mesangial Focal/Diffuse Proliferative GN Lupus Nephritis, Post-infectious (early phase) Nephritic Membranoproliferative GN SLE, Hep B & C, HIV, Lymphoma Nephrotic Nephritic IgA nephropathy Celiac, IBD, Nephritic Anti-GBM Goodpasture Nephritic 11 12 Glomerular Filtration n Size n Freely filterable: < 10,000 molecular wt. n Main size barrier: basement membrane n Shape n Easily filterable: slender & flexible n Electric charge n Negative charge: endothelial cells, podocytes & glomerular basement membrane n Main electric barrier: lamina fenestra & inner BM 13 14 Glomerular Filtration Rate n Starling forces n GFR = Kf (PGC PBS COP) n GFR is high (180 L/day) n Large porous surface n High transmural pressure gradient n PGC = 55 mm Hg; PBS = 15 mm Hg; COP = 30 n Outward filtration occurs along length of capillary 15 Glomerular filtration: Starling forces 16 17 Glomerular Hydrostatic Pressure n Constant between MAP of 80-180 mm Hg n Glomerular filtration ceases: < 40-50 mm Hg n Renal Autoregulation of blood flow...
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Renal_Physiology_11 - Renal Function n Regulate osmotic...

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