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Female_breast_09 - 1 2 3 50 of malignant tumors 20 of...

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50% of malignant tumors } 20% of malignant tumors 4
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Breast Development Embryonic/Fetal Wk 7-8: mammary glands differentiate on epidermal ridge from axilla to groin Potential site for supernumerary nipples 5 th mo.: mammary buds differentiate into lactiferous ducts & are separated into lobules Puberty Estrogen: growth & branching of ducts Progesterone acts on alveolar cells Synergism w/ PRL, GH, insulin, cortisol, thyroxine 5
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Pregnancy 1 st trimester: ducts increase 2 nd trimester: new lobules and alveoli Terminal alveolar cells differentiate into secretory cells 6
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Ductal carcinoma in situ 9
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Fibrocystic changes 11
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Fibroadenoma 12
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Infiltrating Ductal carcinoma 13
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Inflammatory carcinoma Peau d’orange (Stage IIIb) 14
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Klein S. Am Fam Physician 2005;71:1731-8 . Evaluation of Palpable Breast Masses 15
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16 Pooled Relative Risks for Breast Cancer Mortality From Mammography Screening Trials for all Age groups Age RR for Breast CA Mortality NN to prevent one
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