Female_Reproductive_Physiology_06

Female_Reproductive_Physiology_06 - FemaleReproductive...

Info iconThis preview shows pages 1–17. Sign up to view the full content.

View Full Document Right Arrow Icon
Female Reproductive  Physiology 1
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Ovarian Function Germ cell maturation Primordial oocyte (arrested in prophase I)    secondary oocyte (arrested in metaphase II) Steroidogenesis Estrogens 17- β  estradiol Estrone Progesterone Androgens Androstenedione Testosterone 2
Background image of page 2
Ovarian Hormones and estrogen secretion LH regulates progesterone secretion Exception:  Estradiol exerts + feedback  prior to ovulation.    GnRH, LH and FSH. 3
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
4
Background image of page 4
5
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Steroidogenesis Two Cell, Two Gonadotropin Hypothesis Granulosa cell, Theca interna cell LH, FSH FSH action restricted to Granulosa cells Only ovarian cell w/ FSH receptors corpus luteum Estradiol:  main steroid product Theca cell androgens converted to estrogens in  granulosa cell via aromatization 6
Background image of page 6
7
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
8
Background image of page 8
FSH                     LH Induces LH receptors  on Granulosa cells in  later stages of maturing   follicle Stimulates progesterone  synthesis  Regulates aromatase  conversion of  testosterone to estrone  Regulates androgen  synthesis in Theca cell Regulates progesterone  synthesis via delta 4  pathway in Theca and  Granulosa cells Regulates rate limiting  step of cholesterol  conversion to  pregnenolone 9
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Estrogens 17- β  estradiol Predominant form pre-menopausal Estrone 1/12 th   activity of estradiol Peripheral conversion of estradiol in liver Predominant form post-menopausal Estriol 1/80 th  activity of estradiol Predominant form in pregnancy 10
Background image of page 10
11
Background image of page 11

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Estrogen Receptors Alpha Endometrium, ovarian stroma, breast CA  cells Beta Granulosa cells, bone, brain, endothelial  cells, prostate gland 12
Background image of page 12
13
Background image of page 13

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Estrogen metabolism Free estrogen:  2-3% Transport Albumin (60%): low affinity Sex hormone binding globulin (SHBG) 40%:  high affinity Hepatic metabolism Hydroxylation 2-hydroxyestrogens 4-hydroxyestrogens & 16- α  hydroxyestrogens Some considered to be genotoxic and carcinogenic 14
Background image of page 14
15
Background image of page 15

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Menstrual Cycle Ovarian Phases Follicular  (10-16 days)
Background image of page 16
Image of page 17
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 02/18/2012 for the course MPAS PA 602 taught by Professor Dr.laird during the Fall '10 term at Chatham University.

Page1 / 45

Female_Reproductive_Physiology_06 - FemaleReproductive...

This preview shows document pages 1 - 17. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online