cardiac_2010 - http:/www.youtube.com/watch?v=GVxJJ2DBPiQ 1...

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http://www.youtube.com/watch?v=GVxJJ2DBPiQ 1
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Coronary Artery Bloodflow Systole  blood flow, especially to L ventricle 10-30% of blood flow during diastole CAD  HR  shortened diastole  impaired coronary flow Diastole  end diastolic pressure impairs coronary flow 18
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Coronary perfusion From epicardial to endocardial surface Systolic compression: greater effect on subendocardial tissue More vulnerable tissue in heart disease 20
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Coronary Vascular Resistance Autoregulated Local metabolites (vasodilation) NO, adenosine, pH, CO2, O2 Sympathetic Norepinephrine Epinephrine (adrenal) 2 vasodilation small arterioles 21
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Sympathetic net effect Small decrease in overall coronary blood flow Increases perfusion to the subendocardial tissue 22
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Coronary Artery Disease (CAD) Plaque   vascular resistance   blood
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This note was uploaded on 02/18/2012 for the course MPAS PA 602 taught by Professor Dr.laird during the Fall '10 term at Chatham University.

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cardiac_2010 - http:/www.youtube.com/watch?v=GVxJJ2DBPiQ 1...

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