Gas_Transport_10

Gas_Transport_10 - GasTransport 1 GasTransport n...

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Gas Transport 1
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Gas Transport n Oxygen transport n Dissolved in blood (2%):  PaO2 n Combined w/ hemoglobin  n  Hemoglobin A (98%): oxyhemoglobin n Methemoglobin: Ferric (Fe+3), not Ferrous (Fe+2); no  binding n Dapsone: Tx of acne; off label for Pneumocystis jiroveci pneumonia n Sulfonamides: eg. sulfamethoxazole (UTI) n Hemoglobin F: higher affinity n Hemoglobin S: lower affinity 2
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3 n Oxygen binding capacity n Maximal amount of O2 bound to Hb n ~ 20 ml O2 / dL   (@ 1.34-1.39 ml O2 / gm Hb) n Depends on Hb concentration n Low in anemia  n Oxygen saturation (SaO2) n % saturation of Hb w/ O2 (98%) n Ratio of actual O2 bound to Hb/ maximal amount  of O2 that can be bound
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n Oxygen content n Total amount of O2 carried in blood n Bound + dissolved n = O2 binding capacity(% saturation)+      dissolved O2 n = (1.34 x Hb x % Sat) + .003 PaO2 n 1.34 ml of O2 per gm of Hb n .003 ml of O2 per 100 ml blood/ mmHg PaO2 4
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Hemoglobin Structure:  2 alpha, 2 beta globins; 4 Heme w/ 4 Iron 5
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T = tense R = relaxed 6
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Gas_Transport_10 - GasTransport 1 GasTransport n...

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