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Femoral_triangle - • Sx – Dull ache in leg worse...

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Thrombosis Pathophysiology Hypercoagulability Genetic causes Factor V Leiden mutation (5-15 % Caucasians) Prothrombin gene mutation Protein C & S deficiencies (rare) Must consider inherited causes in < 50 y/o w/o acquired risk Acquired Prolonged immobilization (bed rest) Tissue damage (surgery –ortho & abdominal , fractures, burns) Anti-phospholipid syndrome 12
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14 Thrombus Activated platelets
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Chronic Venous Insufficiency
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Unformatted text preview: • Sx – Dull ache in leg, worse standing • Signs – Edema, leg circumference, varicosities, erythema, hyperpigmentation, ulceration (medial & lateral malleoli), dermatitis 16 17 18 19 20 21 Lymphedema, idiopathic 22 Chronic lymphedema → fibrosis, sclerosis, cellulitis Filariasis Nematode: (Wuchereria bancrofti)-120 million affected-5%: elephantiasis (superimposed bacterial & fungal infection) 23...
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