Unformatted text preview: all lead to a relative excess in the production of the stickier 42-amino acid form of the beta-amyloid peptide over the less sticky 40-amino acid form. This beta-pleated peptide is postulated to have neurotoxic properties and to lead to an incompletely understood cascade of events resulting in neuronal death, synapse loss, and the formation of neurofibrillary tangles (NFTs) and senile plaques (SPs) among other lesions. Nonetheless, mutations accounting for less than half of all cases of early-onset Alzheimer disease have been found. Other than the ApoE epsilon 4 genotype, no polymorphisms in other genes have been consistently found to be associated with late-onset Alzheimer disease. http://emedicine.medscape.com/article/1134817-overview...
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- Fall '10
- Alzheimer Disease, Alzheimer disease account, cause Alzheimer disease