Amoxicillin - DRUG name (generic and common): Generic:...

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Unformatted text preview: DRUG name (generic and common): Generic: Amoxicillin Common brand names: Amoxil, DisperMox, Trimox, Moxatag, Moxcilin CLASS Aminopenicillin DESCRIPTION (basic summary) Amoxicillin is an oral semisynthtic aminopenicillin. It has a broad spectrum activity against non--lactamase producing gram-positive and gram-negative bacteria. It is commonly used to treat infections such as otitis media, bronchitis, sinusitis, bacterial cystitis, endocarditis prophylaxis, and other common upper respiratory tract infections. It was approved by the FDA in 1974. MECHANISM OF ACTION Amoxicillin inhibits the third stage of bacterial cell wall synthesis by binding to specific penicillin-binding proteins (PBPs) that are located inside the bacterial cell wall. This binding interferes with cell wall synthesis and eventually leads to cell lysis. Aminopenicillins are able to penetrate gram-negative bacteria more readily than are the natural penicillins or penicillinase-resistant penicillins. This is due to the presence of a free amino group. PHARMOKINETICS Absorption-About 80% absorbed by mouth Distribution- 17-20% is protein bound. The drug disperses into the liver, lungs, gallbladder, and muscle. It also may...
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This note was uploaded on 02/18/2012 for the course PAS 600 - 601 taught by Professor Garrubba during the Fall '10 term at Chatham University.

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Amoxicillin - DRUG name (generic and common): Generic:...

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