Antitussive_CD[1] - AntitussiveDrugs

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Antitussive Drugs US FDA recommends that cough and cold medications should not be used in children under 6  yrs commonly include combinations of antihistamines, cough suppressants,  decongestants (such as phenylephrine and pseudoephedrine) Decongestants active alpha and beta adrenoceptors by direct and indirect  mechanisms the activation of alpha-1-adrenoceptors produce vasoconstriction so it  works as a nasal decongestant the activation of beta-adrenoceptors, the drugs produce vasodilation Adverse effects of ephedrine and pseudoephedrine: tachycardia, inc BP,  urinary retention, CNS stimulation, insomnia Pseudoephedrine was replaced by phenylephrine because PSE can be used  to make methamphetamine Antitussives serve purpose of expelling irritating substances such as dust, pollen,  accumulated fluids, inflammatory cells from the upper airways used to suppress cough Cough reflex initiated by stimulation of sensory receptors on afferent (receptors to CNS) nerve  endings located between mucosal cells of pharynx, larynx, and larger airways the impulses ascend via the vagus nerve to the dorsal medulla
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This note was uploaded on 02/18/2012 for the course PAS 600 - 601 taught by Professor Garrubba during the Fall '10 term at Chatham University.

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Antitussive_CD[1] - AntitussiveDrugs

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