Mononucleosis_NW - Learning Issue: Mononucleosis Name:...

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Learning Issue: Mononucleosis Name: Nicole Wood Definition : Infectious mononucleosis (IM) is an acute illness due to Epstein-Barr virus infection, which occurs mainly in adolescents and young adults. *Epstein-Barr virus: the cause of infectious mononucleosis, which is characterized by fever, sore throat, lympthadenopathy, and atypical lymphocytosis. The virus is a member of the family Herpesviridae. *Infectious diseases: Profound fatigue, low-grade fever (A low grade fever ranges from 100.4F to 102.2F), and lymphadenopathy are the hallmarks of infectious dieseases. Signs and Symptoms : Signs: Median % of Patients (Range) Sore throat 75% (50-87) Malaise 47% (42-76) Headache 38% (22-67) Abdominal pain, nausea, or vomiting 17% (5-25) Chills 10% (9-11) Symptoms: Lymphadenopathy 95% (83-100) Fever 93% (60-100) Pharyngitis or tonsilitis 82% (68-90) Splenomegaly 51% (43-64) Hepatomegaly 11% (6-15) Rash 10% (0-25) Periorbital edema 13% (2-34) Jaundice 5% (2-10) *Fever is usually low grade and is most common within the first two weeks of illness; however it may persist for >1 months *Lymphadenopathy and pharyngitis are most prominent during the first 2 weeks of the illness *Splenomegaly is more prominent during the second and third weeks *A papular rash, usually on the arms or trunk, develops in about 5% of cases Risk Factors : Ages between 10 and 30 Populations with many young adults, such as active duty military personnel, high school, and college students Pathophysiology : EBV replicates primarily in beta-lymphocytes, but also replicate in the epithelial cells of the pharynx and parotid duct
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This note was uploaded on 02/18/2012 for the course PAS 600 - 601 taught by Professor Garrubba during the Fall '10 term at Chatham University.

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Mononucleosis_NW - Learning Issue: Mononucleosis Name:...

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