Sickle Cell Anemia - Learning Issue: Are all cells always...

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Learning Issue: Are all cells always sickled in sickle cell anemia, and is there a change in MCV values? Name: Michael Holmes Definition Is a Hemoglobin Disorder Causes The sickle cell syndrome s are caused by a mutation in the B- globin gene that changes the sixth amino acid from glutamic acid to valine. Risk Factors African American Inheritance of HbS from one parent and another hemoglobinopathy from another parent such as B-thatlassemia, or HbC from another parent. Pathophysiology HbS polymerizes reversibly when deoxygenated to form gelatinous network of fibrous polymers that stiffen RBC, membrane, increase vicosity, and cause dehydration due to potassium leakage and calcium influx. These changes also produce the sickle shape. Signs and Symptoms Vasoocclusion painful ischemia Acute pain Tenderness Fever Tachycardia Anxiety Painful cries o Developed pain anywhere in the body o Few hours to 2 weeks Acute chest syndrome Chest pain Tachypnea
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This note was uploaded on 02/18/2012 for the course PAS 600 - 601 taught by Professor Garrubba during the Fall '10 term at Chatham University.

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Sickle Cell Anemia - Learning Issue: Are all cells always...

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