SpleendestructionofRBC_EY

SpleendestructionofRBC_EY - Learning Issue: RBC and the...

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Learning Issue: RBC and the role of the spleen, Erica Young Normal destruction of RBC: Red blood cells normally live for 110 - 120 days. After that, they naturally break down and are usually removed from the circulation by the spleen. The spleen is composed of red pulp and white pulp, which are Malpighi’s terms for the red blood-filled sinuses and reticuolendothelial cell-lined cords and the white lymphoid follicles arrayed within the red pulp matrix. The spleen is in the portal circulation. The blood flows into the spleen at a rate of about 150 mL/min through the splenic artery. Some blood goes from the arterioles to capillaries nand then to the splenic veins and out the spleen., but the majority flows into the macrophage-lined sinuses and cords. The blood entering the sinuses reenter the circulation through the splenic venules, but the blood entering the cords is subjected to an inspection of sorts. In order to return to circulation, the blood cells in the cords must squeeze through the slits in the cord lining
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SpleendestructionofRBC_EY - Learning Issue: RBC and the...

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