Tylenol_RC - DRUG name (generic and common): Acetaminophen...

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DRUG name (generic and common): Acetaminophen Name: Rachel Chacko CLASS Analgesic, Antipyretic DESCRIPTION (basic summary) Acetaminophen has analgesic and antipyretic properties, similar to aspirin. But unlike Aspirin, it does not have peripheral antiflammatory activity or activities on platelet function. Unintentional/misuse of this drug is the number one cause of acute hepatic failure in the US. MECHANISM OF ACTION Exact mechanism is unknown. Thought to act primarily in the CNS and increase pain threshold by inhibiting cyclooxygenase, a collection of enzymes involved in prostaglandin synthesis. Unlike nonsteroidal anti- inflammatory drugs, acetaminophen does not inhibit cyclooxygenase in periphersal tissues, which is the reason for its lack of peripheral anti- inflammatory effects. It is also thought to inhibit the synthesis/acts of chemical mediators that sensitize the pain receptors to mechanical and chemical stimulation. The antipyretic activity of the drug is exerted by blocking the effects of endogenous pyrogen in the hypothalamic heart
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This note was uploaded on 02/18/2012 for the course PAS 600 - 601 taught by Professor Garrubba during the Fall '10 term at Chatham University.

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