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Meds Adverse reaction neuropathies

Meds Adverse reaction neuropathies - muscle paralysis •...

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Template completed by: Michael Holmes Purpose: Adverse drug reaction for neuropathies DRUG name (generic and common): Zocor CLASS Simvastatin is an oral antilipemic agent which inhibits HMG- CoA reductase DESCRIPTION (basic summary) MECHANISM OF ACTION PHARMOKINETICS CONTRAINDICATIONS ADVERSE EFFECTS Amyotrophic lateral sclerosis (ALS, Lou Gehrig's Disease) has been reported to the FDA in a higher than expected number of patients taking statins. ALS is a progressive motor neuron disorder with symptoms such as difficulty walking or standing, difficulty with fine motor skills, atrophy of tongue and hand muscles, dysphagia, dysarthria, and
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Unformatted text preview: muscle paralysis . • Other adverse neurological reactions that have been reported during statin therapy include insomnia, tremor, vertigo, memory loss, and paresthesias . • An association between HMG-CoA reductase inhibitors (statins), including simvastatin, and peripheral neuropathy has been reported in the literature (case series, case-control studies, cohort studies). In a nested case-control study of a Danish population, the odds ratio for idiopathic peripheral neuropathy in 166 patients that ever or were currently taking a statin, was 3.7 (95% CI 1.8—7.6) • INDICATIONS DOSAGE Notes Sources:...
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