orthostatic hypotension drugs

orthostatic hypotension drugs - Learning issue: Medications...

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Learning issue: Medications related to syncope and hypotension Name: Michael Holmes Drugs ( Table 46-1 ) are important causes of orthostatic hypotension . Ideally establishing a causal relationship between a drug and orthostatic hypotension requires identification of the culprit medicine , abolition of symptoms by withdrawal of the drug, and rechallenge with the drug to reproduce symptoms. Rechallenge is often omitted in clinical practice in view of the potential serious consequences. In the presence of polypharmacy, which is common in the older person, it becomes difficult to identify a single culprit drug because of the synergistic effect of different drugs and drug interactions. Thus all drugs should be considered as possible contributors to orthostasis. PATHOPHYSIOLOGY The temporary cessation of cerebral function that causes syncope results from transient and sudden reduction of blood flow to parts of the brain (brain stem reticular activating system) responsible for consciousness. The predisposition to vasovagal syncope starts early and lasts for
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orthostatic hypotension drugs - Learning issue: Medications...

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