Ischemic pain - tissue ATP levels and an accumulation of...

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Learning issue: Ischemia pain -MH (I had a hard time finding the exact physiology of how the pain is created. But this gives a description of the effects of ischemia) If this doesn’t work, please let me know. METABOLIC AND FUNCTIONAL CONSEQUENCES OF ISCHEMIA Because oxygen delivery to the heart is closely coupled to coronary blood flow, a sudden cessation of regional perfusion following a thrombotic coronary occlusion quickly leads to the cessation of aerobic metabolism, depletion of creatine phosphate, and the onset of anaerobic glycolysis. This is followed by the accumulation of tissue lactate, a progressive reduction in
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Unformatted text preview: tissue ATP levels, and an accumulation of catabolites, including those of the adenine nucleotide pool. As ischemia continues, tissue acidosis develops and there is an efflux of potassium into the extracellular space. Subsequently, ATP levels fall below those required to maintain critical membrane function, resulting in the onset of myocyte death. Source: .50051-0--cesec68&isbn=978-1-4160-4106-1&sid=1080535386&type=bookPage&sectionEid=4-u1.0-B978-1-4160-4106-1. .50051-0--cesec68&uniqId=225850941-6#4-u1.0-B978-1-4160-4106-1..50051-0--cesec68...
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